Does Tramadol Help with Headaches? | Simple Guide!

The human body is equivalent to a machine. We all know that if one area of the body is unhappy, the entire body is uncomfortable. Headache is one of the most unpleasant things that any person can go through. It disrupts all of the body’s normal functions, making everything unpleasant for us. 

But, as the pharmaceutical industry advances, new treatments and drugs are developed regularly, making everything much easier and more accessible. Tramadol is one of the medications that are pretty efficient in relieving headaches. Tramadol in the proper dosage provides peace and comfort. Due to the obvious pharmacies right outside the gate, everything is within easy reach.

Medicines are intended for the body’s comfort, but you should know how much you should be taking and that your prescriptions are for the ailment you are suffering from. Migraine headaches can continue for hours, if not days. They have the potential to induce excruciating pain, nausea, and vomiting. They can make you sensitive to light or noise, and they can have an impact on your personal and professional life. 

A prescription for butalbital, an opioid (narcotic) or barbiturate (sedative), may be given to you to treat migraines. These are anti-inflammatories. Tramadol is an opioid, a type of narcotic drug used to relieve mild to moderately severe pain in humans. Keep your eyes peeled for a comprehensive overview of this drug and get your answer on Does Tramadol Help with Headaches?

Tramadol And Its Working

Tramadol is an oral pain reliever used to treat mild to somewhat chronic migraine. Tramadol is a narcotic (opioid) analgesic related to opioids. It alters how your body perceives and responds to pain by acting on the brain. Tramadol is an orally administered narcotic-like pain reliever used to treat moderate to severe pain in adults. 

This drug’s extended-release tablet formulation is used to treat moderate to severe chronic pain that requires 24-hour treatment. This drug requires a doctor’s prescription and is only available. Patients taking this medication should notify their doctors if they experience any problems as a result of using it and any uncommon side effects, symptoms, or bothersome side effects. 

It’s important to follow the directions carefully when using this medication. Most opioid drugs come with a substantial risk of addiction. On the other hand, Tramadol does not pose a significant risk of addiction. Review the patient health information sheet that comes with this medication’s prescription and every time it’s refilled. There could be new healthcare information available. Ultram, Ultram ER, Ryzolt, and ConZip are some of the numerous brand names for tramadol.

Headaches And Tramadol Relation

This study aims to assess the performance and safety of tramadol HCl/acetaminophen as a pain reliever to a placebo in the treatment of acute migraine headache discomfort. Even though tramadol HCl/acetaminophen is prescribed to treat acute pain, it is not approved to treat acute pain associated with migraine headaches. 

The researchers believe that tramadol HCl/acetaminophen is a safe and effective pain reliever for acute pain associated with migraine headaches. Despite the availability of new medications and methods to treat acute migraine pain, there are still gaps in treatment. The components and mechanism of action of tramadol HCl/acetaminophen tablet may be beneficial in treating acute migraine headache discomfort.

Dosage Of Tramadol For Headache

Tramadol is a pain-relieving drug created by humans that can be used to treat moderate to severe pain. According to research, Tramadol and its active metabolite bind to mu-opioid receptors in the central nervous system (brain and spinal cord), activating inhibitory neurons and decreasing pain signals. It also appears to weakly impede serotonin and norepinephrine reuptake, resulting in higher levels of these neurotransmitters at the neuronal synapse. 

After being randomly allocated to a group, patients will leave the study center with one dose (2 tablets) of study medicine, either active therapy or placebo. Tramadol is a narcotic analgesic, which means it relieves pain. Tramadol HCl/acetaminophen is more effective than tramadol alone, and it lasts a lot longer than acetaminophen alone.

Tramadol may be used as a component of a reactive pain management strategy for patients who suffer from chronic migraines. This suggests that migraine sufferers who have headaches with auras more than twice a month are the most likely to benefit from Tramadol. Chewing, crushing, splitting, or dissolving an extended-release capsule or oral tablet is prohibited and used in conjunction with acetaminophen.

Also Read: Headache After Botox: Reasons, and Treatments

Side Effects Of Tramadol

Before using tramadol, consider these things. If you’re in between the ages of 18 and 60, don’t take any other medications, and don’t have any other medical issues, you’re more likely to suffer the following adverse effects:

Several Uncomfortness

Common side effects include headaches, nausea, dizziness, constipation, vomiting, joint pains, dry mouth, sweat, and itchy skin.


Sedation is also regularly noted, impairing a person’s ability to drive, operate machinery, or perform dangerous duties. This impact may be amplified by alcohol.


Dependence, addiction, and reduced breathing are all possible side effects. Tramadol has the prospect to be abused and sought after by drug addicts. Tolerance to the impact may develop.


Tramadol consumption has been linked to seizures. People are taking certain antidepressants (such as SSRIs, SNRIs, TCAs, MAO inhibitors), other opioids, antipsychotics, and other drugs that lower the seizure threshold, as well as those with a pre-existing seizure disorder, head trauma, excessive alcohol use, or a metabolic disorder predisposing to an increased risk of seizures, are at an increased risk.

Breathing Problems

If you combine tramadol with alcohol, sedative drugs, or other narcotic medications, you run the risk of hazardous or catastrophic side effects like delayed breathing.

Risk for age 65

Seniors above 65 may be susceptible to tramadol’s adverse effects. Tramadol should be used with caution, and extended-release tramadol should be avoided if possible.


Some people, such as those with a history of depression or prone to addiction, may not be able to use it. Tramadol has been linked to an increased risk of suicidal thoughts and behaviours.

Respiratory Problems

Tramadol is not recommended for those at risk for respiratory depression, have had a head injury, have high intracranial pressure, or have an acute stomach infection.


Tramadol metabolism may be hindered in those who are CYP 2D6 poor metabolizers. While tramadol concentrations may be higher in these persons, active metabolite tramadol concentrations may be lower, resulting in insufficient pain alleviation.


Serotonin syndrome (problems include mental status changes [such as agitation, hallucinations, coma, delirium]), high heart rate, dizziness, flushing, muscle tremor or rigidity, and gastrointestinal symptoms) can be caused by interaction or overdosage (including nausea, vomiting, and diarrhea)

Allergic Reactions

If you’ve ever had an allergic response to codeine or another opioid, don’t take it. Tramadol use has seldom resulted in anaphylaxis (a potentially fatal allergic reaction), which usually occurs after the first dose. Itchy skin, a rash, breathing difficulties, and other allergy-like symptoms may be more prevalent.

Tips for using Tramadol

Consider the following tips.

Take With Food

Tramadol is a pain reliever that should be taken along with food.

Don’t Chew

Do not crush or chew the long-acting formulation; otherwise, you may obtain a harmful or deadly dose. Tramadol extended-release capsules should only be taken once a day. Do not raise your tramadol dosage unless your doctor has told you to.

Makes Sleepy

It may drive you sleepy and impair your ability to drive or operate machinery. Don’t drive or do anything else possibly dangerous until you’re sure tramadol isn’t causing this.

Avoid Alcohol Consumption with it.

Avoid consuming alcoholic beverages. Tramadol’s adverse effects may be exacerbated by alcohol, increasing the chance of seizures.

It has the potential to make you feel sick. This effect can be countered by taking an antiemetic (anti-sickness medicine) with tramadol. Starting medication with low dosages or taking it with food may also help to decrease nausea.

Don’t Quit abruptly

Do not abruptly quit taking tramadol if you have been taking it for a long time. Your doctor will advise you on the best strategy to gradually reduce the dosage for weeks.

Don’t eat if you are an allergic patient.

If you have an allergic response to tramadol, extreme sweating, feel agitated or disoriented, develop a fever or diarrhea, have trouble controlling your limbs, or observe spasmodic jerky contractions of your muscles, see a doctor immediately.

Keep pets and kids far

Keep pets and youngsters out of reach. Keep your medicine in a secure, private storage space, away from the eyes of anyone who might try to use it illegally.

Avoid in Pregnancy

If you’re pregnant or breastfeeding, don’t use it unless your doctor says so.

Also Read: Headaches After Tooth Extraction: Causes and Treatments

Response and effectiveness

Two hours after oral tramadol treatment, peak levels of immediate-release tramadol are reached. Extended-release tramadol pills reach their peak levels after 10 to 12 hours. There is a lot of variation in how people respond to tramadol; for the same amount of pain relief, some people may need greater or lower dosages than others.

  • Side effects such as nausea, dizziness, and headache may be reduced by starting at the lowest possible dose and gradually increasing it.
  • To avoid withdrawal symptoms, it’s best to go off tramadol therapy gradually. A timetable will be given to you by your doctor.


We talked about tramadol and how it helps relieve headaches, its negative effects and does tramadol help with headaches. Tramadol is a pain reliever that is commonly used to treat chronic diseases like fibromyalgia and migraine headaches. Tramadol is a prescription pain reliever that can be used to treat moderate to severe pain caused by cancer, osteoarthritis, and other musculoskeletal conditions. Tramadol is frequently prescribed following surgery. Tramadol may also be beneficial in the treatment of nerve pain.

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